Distinctive temporal profiles of detergent-soluble and -insoluble tau and Aβ species in human Alzheimer's disease.

•Two distinct phospho-dependent profiles of insoluble tau deposition are apparent.•Soluble tau and Aβ better correlate with AD progression than insoluble measures.•Soluble tau and Aβ better correlate with cognitive decline than insoluble measures.•Soluble Aβ correlate with cognitive decline following end stage case exclusion.•Insoluble fibril amyloid better correlates with AD progression than total Aβ.