Anchoring immunosuppression to inflamed tissue
Nature Biomedical Engineering（2023）
摘要
Fusing the anti-inflammatory enzyme indoleamine 2,3-dioxygenase to the tissue-anchoring protein galectin-3 ameliorates inflammation at the injection site while avoiding systemic immune suppression, as shown in multiple rodent models of inflammation.
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关键词
Immunosuppression,Inflammatory diseases,Protein design,Biomedicine,general,Biomedical Engineering/Biotechnology
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