Allergic Airway Sensitization Impairs Anti-Bacterial IgG Antibody Responses During Bacterial Respiratory Infections.

Arthur H Totten,Li Xiao,Danlin Luo,David Briles,Joanetha Y Hale,Donna M Crabb,Trenton R Schoeb,Ammar Saadoon Alishlash,Ken B Waites,T Prescott Atkinson

Journal of Allergy and Clinical Immunology（2019）

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摘要

An established Type 2-biased host immune response impairs the host immune response to respiratory bacterial infection in a largely pathogen independent manner. Some pathogens, e.g. Mpn, can augment ongoing allergic responses and inhibit pulmonary T2 cytokine responses and allergic airway hyperreactivity.

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关键词

Mycoplasma pneumoniae,Streptococcus pneumoniae,infection,antibody,allergy,cytokines,animal model

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