Fine control of endothelial VEGFR-2 activation: caveolae as fluid shear stress shelters for membrane receptors

Biomechanics and modeling in mechanobiology, 2018.

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Keywords:
CaveolinDiffusion analysisFinite element analysisFlow analysisMembrane mechanicsMore(2+)

Abstract:

Recent experimental evidence points to the possibility that cell surface-associated caveolae may participate in mechanotransduction. The particular shape of caveolae suggests that these structures serve to prevent exposure of putative mechanosensors residing within these membrane invaginations to shear stresses at magnitudes associated wi...More

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