Development and In Vivo Preclinical Imaging of Fluorine-18-Labeled Synaptic Vesicle Protein 2A (SV2A) PET Tracers.

Cristian C Constantinescu,Cedric Tresse,MingQiang Zheng,Alexandra Gouasmat,Vincent M Carroll, Laetitia Mistico,David Alagille,Christine M Sandiego,Caroline Papin,Kenneth Marek,John P Seibyl,Gilles D Tamagnan,Olivier Barret

Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging（2019）

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摘要

We have identified a F-18-labeled tracer ([F]MNI-1126) that exhibits comparable in vivo characteristics and specificity for SV2A to [C]UCB-J in non-human primates, which makes [F]MNI-1126 a promising PET radiotracer for imaging SV2A in human trials.

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关键词

SV2A,F-18,PET imaging,Synaptic density,Neurodegenerative disorders,MNI-126

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