Early Clinical Predictors of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Myeloablative Stem Cell Transplantation.

Lindsey E Roeker,Haesook T Kim,Brett Glotzbecker,Prashant Nageshwar,Sarah Nikiforow,John Koreth,Philippe Armand,Corey Cutler,Edwin P Alyea,Joseph H Antin,Paul G Richardson,Robert J Soiffer,Vincent T Ho

Biology of Blood and Marrow Transplantation（2019）

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摘要

•Allogeneic HSCT patients experience elevated tacrolimus levels, renal dysfunction, and become refractory to platelet transfusion in the week before VOD/SOS diagnosis.•These dynamic clinical markers may aid in the earlier diagnosis of VOD/SOS.

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关键词

VOD,SOS,Tacrolimus,Defibrotide,Veno-occlusive disease,Sinusoidal obstruction syndrome

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