Evaluating the broad-spectrum efficacy of the acetylcholinesterase oximes reactivators MMB4 DMS, HLö-7 DMS, and 2-PAM Cl against phorate oxon, sarin, and VX in the Hartley guinea pig.

•MMB4 DMS and HLö-7 DMS demonstrate superior qualities against CWNA and pesticides.•They both provide significant PR against all three OPs compared to atropine controls.•Significance was not readily observed across the board when compared against 2-PAM Cl.•The ED50 values of MMB4 DMS was lower than other oximes against all three Ops.