Pyridazine-derivatives Enhance Structural and Functional Plasticity of Tripartite Synapse Via Activation of Local Translation in Astrocytic Processes.

Joshua B Foster,Fangli Zhao,Xueqin Wang,Zan Xu, Kuanhung Lin,Candice C Askwith,Kevin J Hodgetts, Chien-Liang Glenn Lin

Neuroscience（2018）

引用 17|浏览12

暂无评分

摘要

•Pyridazine derivatives increase EAAT2 protein expression specifically in perisynaptic astrocytic processes.•EAAT2 and other proteins are locally synthesized in perisynaptic astrocytic processes in response to pyridazine derivatives.•Pyridazine derivative treatment enhances plasticity of the tripartite synapse in the hippocampal circuit.

查看译文

关键词

Ank2,AP-2,APP,AUC,BDNF/NT-3,CDS,CLTB,EAAT1/GLAST,EAAT2,FDR,fEPSP,GABA,GAPDH,GAT1,GDP,GFAP,HPLC,HSC70,HSP90β,LC/MS/MS,LRM,LTP,MAP2ab,NMDAR2B,PAP,PMV,PSD93,PSD95,RIPA,SE,SYT1,SYT7,TBS,UTR,VGLUT1,YWHAG

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要