Three Patients with an Unusual Pattern on Urine Immunofixation.

Three unrelated urine immunofixations, ordered for diagnostic purposes of monoclonal gammopathy of renal significance (MGRS) (1, 2), exhibited several abnormal fractions in the protein electrophoresis lane (Fig. 1, A–C). Corresponding monoclonal fractions were undetectable in the immunofixation lane against γ/α/μ heavy chains and κ or λ (free) light chains. All patients had a medical history of type 1 diabetes mellitus and a combined …