Synthesis and anticancer activity studies of indolylisoxazoline analogues.

M V S K Chaitanya,P O Venkataramana Reddy,Kumar Nikhil,Anil Kumar,Kavita Shah,Dalip Kumar

Bioorganic & Medicinal Chemistry Letters（2018）

引用 8|浏览13

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摘要

•A series of indolylisoxazolines were prepared and assessed for their cytotoxicity.•Isoxazoline derivatives 6c–d, 6i and 6l displayed potent cytotoxicity (IC50 = 2.5–5.0 µM).•Isoxazolines 6c and 6i induced apoptosis and inhibited C4-2 cell migration.

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关键词

Indolylisoxazolines,Isoxazolines,Indole heterocycles,Anticancer activity,Apoptosis

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