Investigating the utility of minimized sample preparation and high-resolution mass spectrometry for quantification of monoclonal antibody drugs.

Tam T T N Nguyen,Ulrik H Mistarz,Narciso Costa,Amaury Herbet,Didier Boquet,François Becher,Kasper D Rand

Journal of Pharmaceutical and Biomedical Analysis（2018）

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摘要

•Three different LC–MS/MS methods using QqQ, Q-TOF and Q-Orbitrap were developed and compared for quantitation of a model mAb in biological fluids.•The capabilities of HRMS combined with a simple sample treatment for fast and sensitive quantification of mAbs in complex matrices were revealed.•The pharmacokinetic properties of Rendomab-B1 in mice over 15 days after administration were determined.

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关键词

Pharmacokinetic,Therapeutic monoclonal antibody,High resolution,Mass spectrometry,Bioanalysis

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