Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction.

Leonardo P. De Carvalho,Sock Hwee Tan,Ghim-Siong Ow,Zhiqun Tang,Jianhong Ching,Jean-Paul Kovalik,Sock Cheng Poh,Chee-Tang Chin,A. Mark Richards,Eliana C. Martinez,Richard W. Troughton,Alan Yean-Yip Fong,Bryan P. Yan,Aruni Seneviratna,Vitaly Sorokin,Scott A. Summers,Vladimir A. Kuznetsov,Mark Y. Chan

JACC: Basic to Translational Science（2018）

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摘要

•Targeted profiling of ceramides identified a 12-ceramide plasma signature that predicted 12-month cardiovascular death, MI, and stroke in 2 prospective cohorts of AMI patients.•Among coronary artery bypass grafting patients, plasma ceramides were higher in those with recent AMI compared with those without recent acute MI.•Analysis of rat ischemic myocardium revealed a consistent increase in ceramide levels and overexpression of 3 enzymes in ceramide biosynthesis.

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关键词

acute coronary syndrome,ceramides,dihydroceramides,major adverse cardiovascular and cerebrovascular events,prognosis,risk prediction

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