Incorporation of NS1 and prM/M are important to confer effective protection of adenovirus-vectored Zika virus vaccine carrying E protein

    Xinglong Liu
    Xinglong Liu
    Linbing Qu
    Linbing Qu
    Xianmiao Ye
    Xianmiao Ye
    Changhua Yi
    Changhua Yi
    Xuehua Zheng
    Xuehua Zheng
    Mingli Hao
    Mingli Hao
    Wan Su
    Wan Su
    Zhipeng Yao
    Zhipeng Yao
    Peihai Chen
    Peihai Chen
    Shengnan Zhang
    Shengnan Zhang
    Yupeng Feng
    Yupeng Feng
    Qian Wang
    Qian Wang

    NPJ vaccines, Volume 3, 2018, Pages 29

    Cited by: 0|Bibtex|Views0|Links
    WOS

    Abstract:

    Current design of Zika virus (ZIKV) vaccine mainly considered envelope (E) as the major target antigen. Non-structural protein NS1 was seldom considered. Herein, we generated three adenovirus-vectored vaccines carrying E (Ad2-E), or premembrane/membrane (prM/M) with E (Ad2-prME), or NS1 in addition to prM/M with E (Ad2-prME-NS1). Ad2-prME...More

    Code:

    Data:

    Your rating :
    0

     

    Tags
    Comments