Shaping the humoral immune response: Actin regulators modulate antigen presentation and influence B-T interactions.

•Antigen presentation by B cells is regulated by intracellular processes relying on conserved regulators of actin cytoskeleton and cell polarity.•Defects in actin cytoskeleton regulators cause severe defects in B cell functionand impair humoral immune responses.•B cells deficient in actin cytoskeleton regulators are impaired in interacting with T cells at the B–T border and seeding GC responses.