Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration.

Michael L Alosco,Yorghos Tripodis,Nathan G Fritts,Amanda Heslegrave,Christine M Baugh,Shannon Conneely, Megan Mariani,Brett M Martin,Samuel Frank,Jesse Mez,Thor D Stein,Robert C Cantu,Ann C McKee,Leslie M Shaw,John Q Trojanowski,Kaj Blennow,Henrik Zetterberg,Robert A Stern

Alzheimer's & Dementia（2018）

引用 83|浏览43

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摘要

•Repetitive head impacts (RHIs) were positively associated with cerebrospinal fluid (CSF) total tau (t-tau) in former National Football League (NFL) players.•Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) was positively associated with CSF t-tau in former NFL players.•sTREM2 strengthened the relationship between exposure to RHI and CSF t-tau.

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关键词

Cerebrospinal fluid,Aβ,sTREM2,Chronic traumatic encephalopathy,Microglial activation,Alzheimer's disease,Repetitive head impacts,Concussion,Subconcussive

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