Left Ventricular Unloading Before Reperfusion Promotes Functional Recovery After Acute Myocardial Infarction.

Michele L Esposito,Yali Zhang,Xiaoying Qiao,Lara Reyelt,Vikram Paruchuri,Gavin R Schnitzler,Kevin J Morine,Shiva K Annamalai,Courtney Bogins,Peter S Natov,Robert Pedicini, Catalina Breton,Andrew Mullin,Emily E Mackey,Ayan Patel,Ethan Rowin,Iris Z Jaffe,Richard H Karas,Navin K Kapur

Journal of the American College of Cardiology（2018）

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摘要

The authors report for the first time that first mechanically reducing LV work before coronary reperfusion with a transvalvular pump is necessary and sufficient to reduce infarct size and to activate a cardioprotective program that includes enhanced SDF-1α activity. Primary unloading further improved LV scar size and cardiac function 28 days after AMI.

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关键词

acute myocardial infarction,cardioprotection,ischemia-reperfusion injury,mechanical circulatory support

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