Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury.

Wencheng Jian,Xinbing Wei,Lin Chen,Ziying Wang,Yu Sun,Shaowei Zhu,Haiyan Lou,Shaoqi Yan, Xinbing Li,Junlin Zhou,Bin Zhang

Neuroscience Letters（2017）

引用 36|浏览14

暂无评分

摘要

•HDAC6 is evidently induced in dopaminergic neurons in Parkinson’s disease (PD).•Acetylation levels of Prx1 and Prx2 decrease after 6-OHDA treatment.•Pharmacological inhibition of HDAC6 ameliorates dopaminergic neurotoxicity.

查看译文

关键词

Histone deacetylase 6,Tubastatin A,Peroxiredoxin,Acetylation,Parkinson's disease

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要