Evaluation of the Relationship Between Cognitive Impairment, Glycometabolism, and Nicotinic Acetylcholine Receptor Deficits in a Mouse Model of Alzheimer's Disease.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging（2019）
摘要
A decrease in cerebral α4β2 nAChR density could act as a biomarker reflecting cognitive impairments associated with AD pathology.
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关键词
Alzheimer’s disease,Nicotinic acetylcholine receptors,2-Deoxy-2-[18F]fluoro-D-glucose ([18F]FDG),5-[123I]Iodo-3-[2(S)-azetidinylmethoxy]pyridine ([123I]5IA),APP/PS2 mice
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