Extracts of Celastrus Orbiculatus Inhibit Cancer Metastasis by Down-regulating Epithelial-Mesenchymal Transition in Hypoxia-Induced Human Hepatocellular Carcinoma Cells

Ya-yun Qian,You-yang Shi,Song-hua Lu,Ting Yang,Xue-yu Zhao,Yan Yan,Wen-yuan Li,Yan-qing Liu

Chinese journal of integrative medicine（2019）

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摘要

COE significantly inhibited the tumor metastasis and EMT by suppressing Hif-1α/Twist1 signaling pathway in hypoxia-induced HepG2 cell. Thus, COE might have potential effect to inhibit the progression of HepG2 in the context of tumor hypoxia.

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关键词

Celastrus Orbiculatus, hepatocellular carcinoma, antimetastasis, epithelial-mesenchymal transition, Hif-1α/Twist1 signaling pathway

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