Furosemide and Albumin for Diuresis of Edema (FADE): A parallel-group, blinded, pilot randomized controlled trial.

•Hyperoncotic albumin increases colloid osmotic pressure, making it an attractive adjunct to diuretics in critically ill patients•This pilot randomized trial tested the feasibility of a definitive study to assess the impact of hyperoncotic albumin in addition to diuretics•The pilot study did not demonstrate feasibility, though it identified challenges which could be addressed prior to a future trial•Patients assigned to albumin had greater increases in colloid osmotic pressure and serum albumin•Physiologic outcomes were similar between the two groups; the study was underpowered to address clinical outcomes