Exendin-4 promotes the vascular smooth muscle cell re-differentiation through AMPK/SIRT1/FOXO3a signaling pathways.

Zihan Liu,Mengqian Zhang,Tengfei Zhou,Qiang Shen,Xiaomei Qin

Atherosclerosis（2018）

引用 28|浏览4

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摘要

•A novel finding that Exendin-4 promotes VSMC redifferentiation in injured vascular, and thus inhibits neointimal formation.•Exendin-4 promotes VSMC redifferentiation as determined by contractile proteins and cytoskeleton reorganization.•The activation of AMPK/SIRT1/FOXO3a pathways mediate the redifferentiation activity of Exendin-4 in VSMCs.

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关键词

Exendin-4,Vascular smooth muscle cells,Re-differentiation,AMPK,Sirtuin1,Forkhead box O3a

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