Recombinant hepatitis C virus genotype 5a infectious cell culture systems expressing minimal JFH1 NS5B sequences permit polymerase inhibitor studies
Virology, Volume 522, 2018, Pages 177-192.
DAADirect acting antiviralsGenotype 5aHCVHepatitis C virusMore(4+)
The six major epidemiologically important hepatitis C virus (HCV) genotypes differ in global distribution and antiviral responses. Full-length infectious cell-culture adapted clones, the gold standard for HCV studies in vitro, are missing for genotypes 4 and 5. To address this challenge for genotype 5, we constructed a consensus full-leng...More
Full Text (Upload PDF)