Recombinant hepatitis C virus genotype 5a infectious cell culture systems expressing minimal JFH1 NS5B sequences permit polymerase inhibitor studies

    Virology, Volume 522, 2018, Pages 177-192.

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    Keywords:
    DAADirect acting antiviralsGenotype 5aHCVHepatitis C virusMore(4+)

    Abstract:

    The six major epidemiologically important hepatitis C virus (HCV) genotypes differ in global distribution and antiviral responses. Full-length infectious cell-culture adapted clones, the gold standard for HCV studies in vitro, are missing for genotypes 4 and 5. To address this challenge for genotype 5, we constructed a consensus full-leng...More

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