Differences in kidney-specific DPP-4 inhibition by linagliptin and sitagliptin.
Diabetes Research and Clinical Practice(2018)
摘要
The two dipeptidyl peptidase (DPP)-4 inhibitors, linagliptin and sitagliptin, were shown to exert different binding kinetics in vitro. Twenty-four hours after oral dosing particularly in vivo inhibition of renal-specific DPP-4 activity was more sustained in Sprague Dawley rats after exposure to linagliptin than it was after sitagliptin.
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