Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model.

A Tarnutzer,F Andreoni,N Keller,C Zürcher,A Norrby-Teglund, R A Schüpbach,A S Zinkernagel

Clinical Microbiology and Infection（2019）

引用 15|浏览11

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摘要

The clear reduction in disease severity in IVIG-treated mice and inhibition of virulence factor activity in mouse and human serum suggest that IVIG may be beneficial in invasive GAS infections such as NF in addition to STSS.

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关键词

Adjunctive treatment,Group A Streptococcus,Necrotizing fasciitis,Polyspecific human intravenous immunoglobulin,Streptococcus pyogenes,Virulence factor activity

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