Ablation treatment of primary and secondary liver tumors under contrast-enhanced ultrasound guidance in field practice of interventional ultrasound centers. A multicenter study.

•Not all tumor nodules are clearly detectable in conventional B-mode US.•Localization and targeting of small HCC nodules and metastases with inadeguate ultrasound may decrease ablation effectiveness.•Contrast enhanced ultrasound can be used to guide percutanepus ablation in the case of undetectable or poorly visible targets.•This study represents a snapshot of the use of CEUS-guided ablation in real practice of Interventional Ultrasound Centers.