ALKBH5-induced demethylation of mono- and dimethylated adenosine.

Timm T Ensfelder, Matthias Q Kurz,Katharina Iwan,Simon Geiger, Sarah Matheisl,Markus Müller,Roland Beckmann,Thomas Carell

CHEMICAL COMMUNICATIONS（2018）

引用 26|浏览5

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摘要

RNA contains methylated A-base derivatives. A methylation to m(6)A and then demethylation regulate homeostasis in mRNA. It is assumed that m(6)A is mainly demethylated by the -ketoglutarate dependent oxidase ALKBH5. Here we show that ALKBH5 also demethylates the dimethylated adenosine m(2)(6)A, which is a non-canonical base present in ribosomal RNA.

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