α-Tocopherol influences glycaemic control and miR-9-3 DNA methylation in overweight and obese women under an energy-restricted diet: a randomized, double-blind, exploratory, controlled clinical trial

Rafaella Cristhine Pordeus Luna, Mayara Karla dos Santos Nunes,Mussara Gomes Cavalcante Alves Monteiro, Cássia Surama Oliveira da Silva,Rayner Anderson Ferreira do Nascimento,Raquel Patrícia Ataíde Lima,Flávia Cristina Fernandes Pimenta, Naila Francis Paulo de Oliveira,Darlene Camati Persuhn, Aléssio Tony Cavalcanti de Almeida,Alcides da Silva Diniz, Cristina Wide Pissetti,Rodrigo Pinheiro Toledo Vianna,Flavia Emília Leite de Lima Ferreira, Maria da Conceição Rodrigues Gonçalves,Maria José de Carvalho Costa

Nutrition & Metabolism（2018）

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摘要

Excess weight is a strong risk factor for the development of dysglycaemia. It has been suggested that changes in the metabolism microRNAs, small non-coding RNAs that regulate gene expression, could precede late glycaemic changes. Vitamin E in turn may exert important functions in methylation and gene expression processes. This study aimed to determine the effect of α-tocopherol on glycaemic variables and miR-9-1 and miR-9-3 promoter DNA methylation in overweight women.

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关键词

DNA methylation,miR-9,miR-9-1,miR-9-3,Haemoglobin A1C,Fasting plasma glucose,α-Tocopherol,Obesity,Diet

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