Role of vitamin D pathway gene polymorphisms on rifampicin plasma and intracellular pharmacokinetics.
PHARMACOGENOMICS(2017)
摘要
We retrospectively evaluate the pharmacogenetic role of single nucleotide polymorphisms involved in rifampicin transport (SLCO1B1, MDR1 and PXR genes) and vitamin D (VDR, CYP24A1 and CYP27B1 genes) metabolism and activity on drug plasma and intracellular concentrations. Patients & methods: Rifampicin C-max and C-trough were measured at weeks 2 and 4 using Ultra-Performance Liquid Chromatographytandem mass spectroscopy methods. Allelic discrimination was performed by realtime polymerase chain reaction. Results: Twenty-four patients were enrolled. At week 2, OATP1B1 521TT and CYP27B1 + 2838CC/CT considering plasma and BsmIAA for intraperipheral blood mononuclear cells C-max, remained in regression analysis. Concerning week 4, TaqITC/CC and CYP24A1 22776CT/TT were retained in plasma C-max regression model. Conclusion: This study confirms the role of SLCO1B1 and it suggests the involvement of vitamin D pathway gene polymorphisms in rifampicin pharmacokinetics.
更多查看译文
关键词
ABCB1,Cdx2,CYP24A1,FokI,pharmacokinetics,TaqI,tuberculosis
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要