The Nuclear Bile Acid Receptor FXR is a PKA- and FOXA2-Sensitive Activator of Fasting Hepatic Gluconeogenesis.

Maheul Ploton,Claire Mazuy,Céline Gheeraert,Vanessa Dubois,Alexandre Berthier,Julie Dubois-Chevalier,Xavier Maréchal,Kadiombo Bantubungi,Hélène Diemer,Sarah Cianférani,Jean-Marc Strub,Audrey Helleboid-Chapman,Jérôme Eeckhoute,Bart Staels,Philippe Lefebvre

Journal of Hepatology（2018）

引用 41|浏览38

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摘要

•FXR synergizes with the glucagon signaling pathway to regulate hepatic gluconeogenesis in vivo and in vitro.•FXR positively regulates gluconeogenic genes through PKA-catalyzed phosphorylation.•The glucagon-regulated transcription factor FOXA2 negatively regulates FXR’s ability to activate the expression of the SHP.

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关键词

Liver,Gluconeogenesis,Glucagon,PKA,Transcription,Nuclear receptor,Bile acid,FXR,FOXA2

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