In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study.

Jue Lin,Jie Sun,Stephanie Wang,Jeffrey M Milush,Chris A R Baker,Michael Coccia,Rita B Effros,Eli Puterman,Elizabeth Blackburn,Aric A Prather,Elissa Epel

Psychoneuroendocrinology（2018）

引用 20|浏览43

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摘要

•PBMCs from caregivers have increased proinflammatory gene expression levels when stimulated in vitro compared to controls.•These genes include NF-κB and many of its cytokine and chemokine targets.•PBMCs from caregivers showed increased Th17 differentiation and increased expression of COX-2 signaling pathway.•Inflammatory gene expression is associated with shorter telomere length prospectively.

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关键词

Chronic stress,Telomere length,Inflammation,NF-κB,In vitro,COX-2

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