HPV RNA in situ hybridization can inform cervical cytology-histology correlation.

Joseph D Coppock, Brian C Willis,Mark H Stoler,Anne M Mills

Journal of the American Society of Cytopathology（2018）

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摘要

LSIL often is overdiagnosed by morphology on biopsy, potentially leading to the false impression that a lesion identified on cytology has been sampled. Performing RNA ISH on biopsies decreases histologic LSIL overdiagnosis, and potentially can prompt further sampling when there is cytology-histology discordance. Cancer (Cancer Cytopathol) 2018. © 2018 American Cancer Society.

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关键词

RNA in situ hybridization,cervical biopsy,cervical cytology,cervical dysplasia,cervical intraepithelial neoplasia grade 1 (CIN1),cytology-histology concordance,human papillomavirus (HPV),low-grade squamous intraepithelial lesion (LSIL),squamous intraepithelial lesion

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