In vitro combinatorial anti-proliferative and immunosuppressive effects of Brucea javanica extract with CX-4945 and imatinib in human T-cell acute lymphoblastic leukemia cells.

•Brucea javanica extract induces caspase-dependent apoptosis of T-ALL cells.•Brucea javanica extract the PMA/PHA-mediated NF-κB signaling pathway and IL-2 production.•Brucea javanica extract suppresses expression of CK2 subunits and Akt phosphorylation.•Combined treatment exerts enhanced inhibitory effects on T-ALL cell viability and IL-2 production.