Genetic modulation of HSPA1A accelerates kindling progression and exerts pro-convulsant effects.

Eva-Lotta von Rüden,Fabio Wolf, Michael Keck,Fabio Gualtieri,Marta Nowakowska,Michael Oglesbee,Heidrun Potschka

Neuroscience（2018）

引用 11|浏览5

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摘要

•HSPA1A overexpression increased seizure susceptibility prior to kindling.•HSPA1A-TG mice presented generalized seizures early during the kindling process.•HSPA1A overexpression accelerates kindling progression.•Toward the end of the experiment, seizure parameters reached comparable levels.

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关键词

CA1 and CA3,EEG,HMGB1,hsp70,Iba1,iNOS,PTZ,TG,TLR,WT

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