Randomized trial comparing the safety and antibody responses to live attenuated versus inactivated influenza vaccine when administered to breastfeeding women.

Rebecca C Brady,Lisa A Jackson,Sharon E Frey,Andi L Shane,Emmanuel B Walter,Geeta K Swamy,Elizabeth P Schlaudecker,Elena Szefer,Mark Wolff,Monica Malone McNeal,David I Bernstein,Mark C Steinhoff

Vaccine（2018）

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摘要

•Prospective, randomized, comparative trial of LAIV versus IIV in women who are actively breastfeeding infants.•One (1%) possible transmission of LAIV from a mother to her infant who remained well.•No LAIV virus was detected in human milk.•Serum and breast milk antibody titers were higher in IIV compared to LAIV recipients.

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关键词

Live attenuated influenza vaccine,Inactivated influenza vaccine,Breastfeeding,Infants,Safety,Immunogenicity

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