5T4 is associated with favorable outcome for mesothelioma and a target for antibody drug conjugates.

Laurel M Schunselaar,Kim Monkhorst,Vincent van der Noort,Ruud Wijdeven,Dennis Peters,Wilbert Zwart,Jacques Neefjes,Paul Baas

Journal of Thoracic Oncology（2018）

引用 5|浏览3

暂无评分

摘要

The 5T4 antigen is expressed in mesothelioma and 5T4-based ADCs are internalized in lysosomes. Two out of three ADCs were capable of killing the mesothelioma cells, the third ADC required additional lysosomal neutralization for its effect. 5T4-based ADC would be a selective strategy for the treatment of mesothelioma.

查看译文

关键词

Malignant pleural mesothelioma,5T4,Antibody-drug conjugate,Lysosome,treatment

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要