Fibrinolytic potential of DS-1040, a novel orally available inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa).

Kengo Noguchi,Naoko Edo,Naoki Miyoshi, Aya Isobe,Akiko Watanabe,Yusuke Ito,Yoshiyuki Morishima,Kyoji Yamaguchi

Thrombosis Research（2018）

引用 11|浏览7

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摘要

An activated thrombin-activatable fibrinolysis inhibitor (TAFIa) attenuates fibrinolysis by removing C-terminal lysine/arginine residues from partially degraded fibrin. We have identified a novel low-molecular-weight inhibitor of TAFIa, DS-1040, to be potentially useful for treating thrombotic diseases.

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关键词

APTT,TAFIa,PCI,CPN,PRP,PT,rt-PA,TF,t-PA

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