Methods for Studying the Function of Progranulin in Atherosclerosis Using Both Knockout Mice Models and In Vitro Studies.

Progranulin (PGRN) has been reported to be associated with cell proliferation, cell growth, wound healing, and inflammation. PGRN mutations are known to be related to dementia. However, the association between PGRN and atherosclerosis remains to be elucidated. Therefore, we generated PGRN-/-ApoE-/- mice to analyze the effect of PGRN on the development of atherosclerosis.