A simulation study comparing slope model with mixed-model repeated measure to assess cognitive data in clinical trials of Alzheimer's disease.

Yun-Fei Chen,Xiao Ni,Adam S Fleisher,Wei Zhou,Paul Aisen,Richard Mohs

Alzheimer's & Dementia: Translational Research & Clinical Interventions（2018）

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摘要

In clinical trials of Alzheimer's disease, mixed-model repeated measure analysis with relaxed assumptions on disease progression seems to be preferred. The slope model might be more powerful if the trajectory has little departure from linearity.

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关键词

Clinical trials efficiency,Mixed-effects models,Mixed-model repeated measure (MMRM),Quantitative review

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