Coexistence of EGFR, KRAS, BRAF, and PIK3CA Mutations and ALK Rearrangement in a Comprehensive Cohort of 326 Consecutive Spanish Nonsquamous NSCLC Patients.

Paloma Martín Martorell,Marisol Huerta, Amparo Compañ Quilis,Rosario Abellán,Enrique Seda,Sebastián Blesa,Felipe J Chaves, Diego Dualde Beltrán,Susana Roselló Keränen,José Franco,Amelia Insa

Clinical Lung Cancer（2017）

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摘要

Driver mutations can coexist in nonsquamous NSCLC. In our cohort, 12.3% of cases with stage IV disease had multiple mutations. Targeted treatment might not be as effective in patients with coexisting mutations; however, coexistence with PIK3CA might not preclude a response.

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关键词

Driver mutation,Mutational co-existence,Next-generation sequencing (NGS),Non–small-cell lung cancer,Treatment response

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