Direct evidence for the age-dependent demise of GNAS-mutated cells in oral fibrous dysplasia.

Yu Isobe,Katsu Takahashi,Honoka Kiso,Kazumasa Nakao,Masayuki Ikeno,Noriaki Koyama,Manabu Sugai,Akira Shimizu,Hironori Haga,Kazuhisa Bessho

Archives of Oral Biology（2018）

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摘要

•The relationship between lesion growth and mutation prevalence within a lesion.•The mutation prevalence differed between lesions.•The first direct evidence for the age-dependent demise of mutated cells in fibrous dysplasia.

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关键词

FD,GNAS,MFD,PFD,Arg201,Cys,His,Gln227,ALP,CT,BMP2,PCR

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