Impaired expression and function of TLR8 in chronic HBV infection and its association with treatment responses during peg-IFN-α-2a antiviral therapy.

Guangying Deng,Jun Ge,Chao Liu,Jinke Pang,Zuxiong Huang,Jie Peng,Jian Sun,Jinlin Hou,Xiaoyong Zhang

Clinics and Research in Hepatology and Gastroenterology（2017）

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摘要

TLR8 expression and function in PBMCs were impaired by chronic HBV infection. Higher TLR8 expression after treatment week 12 could potentially predict complete response to peg-IFN-α-2a therapy.

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关键词

ALT,CHB,CM,CR,HBeAg,HBsAg,HBV,HC,ICS,IFN,IL,MFI,NCR,NK cells,PBMC,peg-IFN-α-2a,TLR,TNF-α,ULN

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