Sprague Dawley rats: A model of successful heart aging.

Daniele Capitanio,Roberta Leone,Chiara Fania,Enrica Torretta,Cecilia Gelfi

EuPA Open Proteomics（2016）

引用 6|浏览12

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摘要

•Sprague Dawley rat hearts of 6, 22 and 30 months were analysed by DIGE and blotting.•Results indicate that this animal model experiences the so-called successful aging.•Mybpc3, Aldh2 and serpins could be used as early biomarkers.•Sirtuin-3 increment suggests the activation of protective non-canonical autophagy.

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关键词

Successful aging,Animal model,2-D DIGE,Mass spectrometry,Heart proteome

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