Deregulation of calcium homeostasis in Bcr-Abl-dependent chronic myeloid leukemia.

Hélène Cabanas,Thomas Harnois,Christophe Magaud,Laëtitia Cousin,Bruno Constantin,Nicolas Bourmeyster,Nadine Déliot

Oncotarget（2018）

引用 12|浏览9

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摘要

The tyrosine kinase activity seems to regulate calcium entries probably not directly but through a global cellular reorganization involving a PKC pathway. Altogether, calcium entries are deregulated in Bcr-Abl-expressing cells and could represent an interesting therapeutic target in combination with TKI.

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关键词

STIM1/Orai1/TRPC1,calcium homeostasis,chronic myeloid leukemia,leukemogenesis,store-operated calcium entry

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