LDL extracellular vesicle coagulation protein levels change after initiation of statin therapy. Findings from the METEOR trial

Laura Verbree-Willemsen,Ya-Nan Zhang,Crystel M. Gijsberts,Arjan H. Schoneveld,Jiong-Wei Wang,Carolyn S.P. Lam, Floor Vernooij,Michiel L. Bots,Linda M. Peelen,Diederick E. Grobbee,Joel S. Raichlen,Dominique P.V. de Kleijn

International Journal of Cardiology（2018）

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摘要

•LDL associated extracellular vesicles (LDL-EVs) are involved coagulation processes.•This study investigates the effect of statins on coagulation proteins in LDL-EVs.•Rosuvastatin increases plasminogen and von Willebrand factor in LDL-EVs.•LDL-EVs are identified as a possible intermediate between statins and coagulation.

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关键词

Coagulation,Statin,Extracellular vesicles,Low-density lipoprotein,Plasminogen,von Willebrand factor

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