Novel orthobunyavirus identified in the cerebrospinal fluid of a Ugandan child with severe encephalopathy.

Arthur W D Edridge,Martin Deijs,Ruth Namazzi,Cosimo Cristella,Maarten F Jebbink,Irma Maurer,Neeltje A Kootstra,Linda R Buluma,Job B M van Woensel,Menno D de Jong,Richard Idro,Michael Boele van Hensbroek,Lia van der Hoek

CLINICAL INFECTIOUS DISEASES（2019）

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摘要

A Ugandan child with an unexplained encephalitis was investigated using viral metagenomics. Several sequences from all segments of a novel orthobunyavirus were found. The S-segment, used for typing, showed 41% amino acid diversity to its closest relative. The virus was named Ntwetwe virus, after the hometown of the patient.

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virus discovery,orthobunyavirus,CNS infection,Uganda,encephalitis

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