The effect of zinc acexamate on oxidative stress, inflammation and mitochondria induced apoptosis in rat model of renal warm ischemia.

Najet Hadj Abdallah,Anna Baulies,Ahlem Bouhlel,Mohamed Bejaoui,Mohamed Amine Zaouali,Safa Ben Mimouna,Imed Messaoudi,José Carlos Fernandez-Checa,Carmen García Ruiz,Hassen Ben Abdennebi

Biomedicine & Pharmacotherapy（2018）

引用 16|浏览15

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摘要

•Zinc acexamate preserves renal morphology and function after I/R.•Zinc acexamate prevents I/R-induced oxidative stress.•Zinc acexamate decreases the production of pro-inflammatory cytokines.•Zinc acexamate improves mitochondrial membrane integrity and decreases apoptosis.

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关键词

Zinc acexamate,Zinc,Ischemia reperfusion injury,Oxidative stress,Inflammation,Mitochondria

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