SEN1500, a novel oral amyloid-β aggregation inhibitor, attenuates brain pathology in a mouse model of Alzheimer's disease.

D Brunner,S Flunkert, J Neddens,S Duller, D I C Scopes,J M Treherne,B Hutter-Paier

Neuroscience Letters（2017）

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摘要

•SEN1500 reduces insoluble aggregated brain amyloid in APPSL mice.•SEN1500 reduces activated microglia in the cortex of APPSL mice.•SEN1500 is a novel candidate for further development in AD clinical trials.

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关键词

Aggregation inhibitor,Amyloid-β,SEN1500,Pharmacotherapy,Plaques,Activated microglia

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