Highly Reactive Thiol-Norbornene Photo-Click Hydrogels: Toward Improved Processability.
MACROMOLECULAR RAPID COMMUNICATIONS(2018)
摘要
In the present work, gelatin type B is modified with highly reactive norbornene functionalities (Gel-NB) following a one-pot synthesis approach to enable subsequent thiol-ene photo-click crosslinking. The modification strategy displays close control over the amount of introduced functionalities. Additionally, Gel-NB exhibits considerably improved processing capabilities in terms of two-photon polymerization when benchmarked to earlier-reported crosslinkable gelatin derivatives (e.g., gelatin-methacrylamide (Gel-MOD) and gelatin-methacrylamide-aminoethylmethacrylate (Gel-MOD-AEMA)). The improvement is especially apparent in terms of minimally required laser power (20 mW vs >= 60 mW (Gel-MOD) vs >= 40 mW (Gel-MOD-AEMA) at 100 mm s(-1) scan speed) and processable concentration range (>= 5 w/v% vs >= 10 w/v% (Gel-MOD/Gel-MOD-AEMA)). Furthermore, the proposed functionalization scheme maintains the excellent biocompatibility and cell interactivity of gelatin. Additionally, the norbornene functionalities have potential for straightforward postprocessing thiol-ene surface grafting of active molecules. As a consequence, a very promising material toward tissue engineering applications and more specifically, biofabrication, is presented.
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关键词
gelatin,hydrogels,thiol-ene photo-click,tissue engineering,two-photon polymerization
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