Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension.
JACC: Basic to Translational Science(2018)
摘要
•The effects of apelin on pulmonary hemodynamics in patients with PAH are unknown.•Systemic infusion caused a significant reduction in pulmonary vascular resistance and increase in cardiac output without a change in heart rate or systemic vascular resistance.•This effect was most prominent in the subgroup of patients receiving concomitant PDE5 inhibition.•Apelin agonism is a novel potential therapeutic target for PAH.
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关键词
apelin,APJ,human,pulmonary arterial hypertension
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