Multi-laboratory evaluation of 1,3-propane sultone, N-propyl-N-nitrosourea, and mitomycin C in the Pig-a mutation assay in vivo.

Young-Shin Chung,Bumsoo Pak, Sehee Han,Jiyeon Lee,Jiyoung Kim,Seng-Min Back,Cho-Rong Park,Su-Hwan Kim,Jong-Kwon Lee

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2018）

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摘要

•N-Propyl-N-nitrosourea, an alkylating agent, increased the frequency of Pig-a mutant cells.•Mitomycin C, a DNA inter-strand cross-linker, increased the frequency of Pig-a mutant cells.•Pig-a assay carried in three laboratories revealed reproducible and concordant results.•Pig-a, micronucleus and comet assays in same rats provided a comprehensive assessment of genotoxicity.

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关键词

CD59-deficient erythrocytes,CD59-deficient reticulocytes,Flow cytometry,Micronucleus assay,Comet assay

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